MARKERS OF MEK INHIBITOR RESISTANCE IN LOW-GRADE SEROUS OVARIAN CANCER: EGFR IS A POTENTIAL THERAPEUTIC TARGET

Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target

Abstract Background Although low-grade serous ovarian cancer Stereo Systems (LGSC) is rare, case-fatality rates are high as most patients present with advanced disease and current cytotoxic therapies are not overly effective.Recognizing that these cancers may be driven by MAPK pathway activation, MEK inhibitors (MEKi) are being tested in clinical t

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New high-entropy alloy superconductor Hf21Nb25Ti15V15Zr24

High-entropy alloys are a new Boy Short class of alloys, and attract much attention due to their unique properties.Since the discovery of a superconducting high-entropy alloy (HEA) in 2014, the materials research on HEA superconductor is a hot topic.We have found that Hf21Nb25Ti15V15Zr24 body-centered-cubic (BCC) HEA is a new superconductor with th

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Complex evaluation of clinical and instrumental data for grounding of the tactics of operative treatment in patients with resistant epilepsy forms

Frequent epileptic seizures and side Rectangle Lift Cocktail Table effects of drugs have a significant negative impact on the quality of life.The main goal in the treatment of such patients is not only to decrease the number of attacks and their severity, but also to improve social adaptation.Surgical treatment for some forms of pharmacoresistant e

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Sensors in Bone: Technologies, Applications, and Future Directions

Osteoporosis, a prevalent ailment worldwide, compromises bone strength and resilience, particularly afflicting the elderly population.This condition significantly heightens susceptibility to fractures even from trivial incidents, such as minor falls or impacts.A major challenge in diagnosing osteoporosis is the absence of discernible symptoms, allo

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